Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 5/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076712 | 0.91 | MMP13 (0.83) | MMP13HTTNPSR1MMP1MMP8 | |
| SCHEMBL7207578 | 0.83 | MMP13 (1.00) | MMP13HTTNPSR1MMP1MMP8 | |
| SCHEMBL1939507 | 0.79 | PLCG1 (0.52) | MMP13MMP1MMP8CA1CA2 | |
| SCHEMBL9703007 | 0.78 | HTT (0.66) | MMP13HTTNPSR1MMP1MMP8 | |
| SCHEMBL7647099 | 0.76 | MMP13 (0.57) | MMP13HTTNPSR1MMP1MMP8 | |
| SCHEMBL4190555 | 0.75 | HTT (0.67) | MMP13HTTNPSR1MMP1MMP8 | |
| SCHEMBL7744256 | 0.74 | MMP13 (0.55) | MMP13HTTNPSR1MMP1MMP8 | |
| SCHEMBL6708168 | 0.74 | PKM (0.64) | MMP13HTTNPSR1MMP1MMP8 | |
| SCHEMBL3250372 | 0.74 | PKM (0.64) | MMP13HTTNPSR1MMP1MMP8 | |
| SCHEMBL7207772 | 0.73 | MMP13 (0.71) | MMP13HTTNPSR1MMP1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130271-A1 | 1,3-Diheterocyclic metalloprotease inhibitors | THE PROCTER & GAMBLE COMPANY | 2003-07-10 | — | — | US | disclosed |
| EP-0939628-B1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-0927168-B1 | 1,3-DIHETEROCYCLIC METALLOPROTEASE INHIBITORS | PROCTER & GAMBLE (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6469000-B1 | TREATING ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS, SKIN DISORDERS, OCULAR DISORDERS, INFLAMMATION AND GUM DISEASE | THE PROCTER & GAMBLE CO. | 2002-10-22 | — | — | US | disclosed |
| US-6465474-B1 | TREATMENT OF SUCH AS OSTEOARTHITIS, RHEUMATOID ARTHRITIS, PREVENTION OR ARREST OF TUMOR GROWTH AND METASTASIS, CORNEAL ULCERATION, LACK OF CORNEAL HEALING, MACULAR DEGENERATION, PERIODONTAL DISEASE, GINGIVITIS | THE PROCTER & GAMBLE COMPANY | 2002-10-15 | — | — | US | disclosed |
| US-6150370-A | 1,3-DINITROCYCLIC COMPOUND TREATS NUMEROUS DISEASES CAUSED BY UNDESIRED METALLOPROTEASE ACTIVITY, SUCH AS TUMOR METASTASIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, SKIN INFLAMMATION, ULCERATIONS, AND PERIODONTITIS | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| US-6013649-A | BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS | MONSANTO COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130271-A1 | 1,3-Diheterocyclic metalloprotease inhibitors | ADAM17, TIMP3, MMP3 | MMP13 15/4885HTT 3468/4885NPSR1 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.