Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.58 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11783483 | 0.85 | ALDH1A1 (0.44) | ESR1ESR2HSD17B1HSD17B2GABRA1 | |
| SCHEMBL7748990 | 0.84 | ESR1 (0.56) | ESR1ESR2HSD17B1HSD17B2CYP2D6 | |
| SCHEMBL6516890 | 0.82 | ESR1 (0.52) | ESR1ESR2HSD17B1HSD17B2AR | |
| SCHEMBL298393 | 0.79 | ESR1 (0.62) | ESR1ESR2KLF10HSD17B1CYP2D6 | |
| SCHEMBL7744370 | 0.76 | ESR1 (0.47) | ESR1ESR2HSD17B1HSD17B2GABRA1 | |
| SCHEMBL21232297 | 0.76 | ESR1 (0.74) | ESR1ESR2KLF10HSD17B1CYP2D6 | |
| SCHEMBL4399352 | 0.75 | ESR1 (0.72) | ESR1ESR2KLF10HSD17B1CYP2D6 | |
| SCHEMBL20762234 | 0.75 | ESR1 (0.57) | ESR1ESR2KLF10CYP2D6GABRA1 | |
| SCHEMBL4648494 | 0.75 | ESR1 (0.66) | ESR1ESR2KLF10AR | |
| SCHEMBL8062965 | 0.75 | ESR1 (0.71) | ESR1ESR2KLF10HSD17B1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001032744-A1 | POLYCARBONATES SUITABLE FOR USE IN OPTICAL ARTICLES | GENERAL ELECTRIC COMPANY (US) | 2001-05-10 | — | — | WO | disclosed |
| US-6177537-B1 | COPOLYMERS OF BISPHENOLS AND SPIRODIINDANEDIOLS | GENERAL ELECTRIC COMPANY | 2001-01-23 | — | — | US | disclosed |