Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 9/20 | 0.82 |
| ▸ | KCNK9 | Q9NPC2 | 8/20 | 0.82 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.74 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298254 | 0.91 | KCNK3 (1.00) | KCNK3KCNK9RAB9ASIRT1KMT2A | |
| SCHEMBL13986890 | 0.88 | RAB9A (0.77) | KCNK3KCNK9CACNA1BAPBA1RAB9A | |
| SCHEMBL7500312 | 0.87 | KMT2A (0.84) | KCNK3KCNK9RAB9ASIRT1KMT2A | |
| SCHEMBL14715827 | 0.87 | KCNK3 (0.92) | KCNK3KCNK9RAB9ASIRT1KMT2A | |
| SCHEMBL14715912 | 0.87 | KCNK3 (0.92) | KCNK3KCNK9RAB9ASIRT1KMT2A | |
| SCHEMBL23577148 | 0.86 | KCNK3 (0.82) | KCNK3KCNK9RAB9ASIRT1KMT2A | |
| SCHEMBL18953533 | 0.85 | KCNK3 (0.89) | KCNK3KCNK9RAB9ASIRT1KMT2A | |
| SCHEMBL14715832 | 0.85 | KCNK3 (0.88) | KCNK3KCNK9RAB9ASIRT1KMT2A | |
| SCHEMBL94608 | 0.85 | RAB9A (0.72) | KCNK3KCNK9CACNA1BAPBA1RAB9A | |
| SCHEMBL1901172 | 0.84 | ALDH1A1 (0.76) | RAB9AKMT2AMEN1POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | claimed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | claimed |
| EP-2291352-B1 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NAT RECH SCIENT (FR) | 2017-09-13 | — | — | EP | disclosed |
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | disclosed |