Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8577372 | 1.00 | ADORA3 (0.41) | ADORA3ADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL6198119 | 0.92 | ADRA1D (0.38) | ADORA3ADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL6196041 | 0.88 | ALDH1A1 (0.41) | ADORA3ADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL7674379 | 0.78 | ADRA1D (0.51) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6196834 | 0.78 | ADRA1D (0.51) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7162576 | 0.76 | ADRA1D (0.54) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6193641 | 0.76 | ADRA1D (0.54) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7991592 | 0.75 | ADRA1D (0.43) | ADORA3ADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL6715316 | 0.74 | CACNA1F (0.44) | ADORA3ADRA1DADRA1AADRA1B | |
| SCHEMBL6784838 | 0.73 | ADRA1A (0.39) | ADORA3ADRA1DADRA1AADRA1BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001022919-A2 | SPIRO[BICYCLIC -AZACYCLOALKYL AND -CYCLOALKYL] DERIVATIVES AND USES THEREOF | MERCK & CO., INC. (US) | 2001-04-05 | — | — | WO | disclosed |