Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7757639 | 0.92 | HTR2C (0.53) | HTR1AHTR1DHTR2CTAAR1SLC6A2 | |
| SCHEMBL7752945 | 0.88 | HTR1A (0.58) | HTR1AHTR1DHTR2CTAAR1SLC6A2 | |
| SCHEMBL95790 | 0.79 | HTR2C (0.61) | HTR1AHTR1DHTR2CSLC6A2HCRTR2 | |
| SCHEMBL7755582 | 0.78 | MTNR1A (0.51) | HTR1AHTR1DHTR2CALDH1A1 | |
| SCHEMBL172889 | 0.75 | HTR1A (0.57) | HTR1AHTR1DHTR2CHCRTR2ALDH1A1 | |
| SCHEMBL8130244 | 0.75 | HTR1A (0.57) | HTR1AHTR1DHTR2CTAAR1KIF11 | |
| SCHEMBL6215060 | 0.72 | HTR1A (0.57) | HTR1AHTR1DHTR2CHCRTR2DRD2 | |
| SCHEMBL6339887 | 0.72 | HTR1A (0.55) | HTR1AHTR1DHTR2CSLC6A2SLC6A4 | |
| SCHEMBL8568951 | 0.71 | MTNR1A (0.38) | NUDT1BACE1 | |
| SCHEMBL8568956 | 0.71 | MTNR1A (0.38) | NUDT1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721947-B1 | Alkyl(hetero)cyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-03-14 | — | — | EP | disclosed |
| US-5703121-A | SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-12-30 | — | — | US | disclosed |
| EP-0721947-A1 | Alkyl(hetero)cyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-07-17 | — | — | EP | disclosed |