Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7753270 | 0.83 | LMNA (0.52) | SMN1; SMN2HTTALDH1A1POLBMAPT | |
| SCHEMBL7752940 | 0.81 | — | — | |
| SCHEMBL7752928 | 0.81 | — | — | |
| SCHEMBL6546897 | 0.76 | MEN1 (0.52) | PKMMAPK1ALDH1A1POLB | |
| SCHEMBL6812211 | 0.75 | CASP1 (0.57) | SMN1; SMN2PKMTP53HTTNPSR1 | |
| SCHEMBL7755341 | 0.74 | MAPK1 (0.56) | SMN1; SMN2PKMMAPK1TP53HTT | |
| SCHEMBL6545622 | 0.74 | CYP1A2 (0.54) | HTTNPSR1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL7753891 | 0.74 | ABCB1 (0.57) | SMN1; SMN2MAPK1HTTALDH1A1POLB | |
| SCHEMBL7752909 | 0.74 | MAPT (0.68) | SMN1; SMN2PKMMAPK1TP53NPSR1 | |
| SCHEMBL6546175 | 0.74 | PKM (0.55) | PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068176-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | Jomaa, Hassan (DE) | 2001-01-17 | — | — | EP | disclosed |
| WO-2000027803-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | JOMAA, HASSAN (DE) | 2000-05-18 | — | — | WO | disclosed |