Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546897 | 0.87 | MEN1 (0.52) | POLBMAPK1KDM4EALDH1A1MEN1 | |
| SCHEMBL7755341 | 0.82 | MAPK1 (0.56) | POLBMAPK1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL7754151 | 0.81 | LMNA (0.66) | ABCB1RAB9APOLBMAPK1NPC1 | |
| SCHEMBL7754219 | 0.80 | MEN1 (0.51) | MEN1KMT2A | |
| SCHEMBL7752909 | 0.79 | MAPT (0.68) | MAPK1SMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL6545433 | 0.79 | MAPK1 (0.58) | POLBMAPK1MAPTHTTALDH1A1 | |
| SCHEMBL6546175 | 0.79 | PKM (0.55) | ALDH1A1LMNA | |
| SCHEMBL7753274 | 0.79 | SMN1; SMN2 (0.55) | POLBMAPK1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL7753921 | 0.78 | MEN1 (0.54) | HCAR2MEN1KMT2A | |
| SCHEMBL6812211 | 0.78 | CASP1 (0.57) | POLBSMN1; SMN2HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068176-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | Jomaa, Hassan (DE) | 2001-01-17 | — | — | EP | disclosed |
| WO-2000027803-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | JOMAA, HASSAN (DE) | 2000-05-18 | — | — | WO | disclosed |