Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 15/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7757677 | 0.93 | MTNR1A (0.54) | MTNR1AMTNR1BALDH1A1KDM4EHTR1A | |
| SCHEMBL7757152 | 0.90 | MTNR1A (0.50) | MTNR1AMTNR1BHTR1AHTR1DHTR2C | |
| SCHEMBL132847 | 0.80 | MTNR1A (0.66) | MTNR1AMTNR1BHTR2CNQO2 | |
| SCHEMBL7752947 | 0.78 | HTR1A (0.56) | ALDH1A1HTR1AHTR1DHTR2C | |
| SCHEMBL6210723 | 0.76 | HTR1A (0.46) | HTR1AHTR1DHTR2CMAPT | |
| SCHEMBL8574792 | 0.75 | MTNR1A (0.58) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8574790 | 0.75 | MTNR1A (0.58) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL138000 | 0.72 | MTNR1A (0.51) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL135119 | 0.71 | MTNR1A (0.65) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7757639 | 0.71 | HTR2C (0.53) | HTR1AHTR1DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041702-A1 | MODULATORS OF CIRCADIAN RHYTHMS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-03-04 | — | — | WO | disclosed |
| EP-0721947-B1 | Alkyl(hetero)cyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-03-14 | — | — | EP | disclosed |
| US-5703121-A | SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-12-30 | — | — | US | disclosed |
| EP-0721947-A1 | Alkyl(hetero)cyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-07-17 | — | — | EP | disclosed |