Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.46 |
| ▸ | MMP3 | P08254 | 13/20 | 0.46 |
| ▸ | MMP7 | P09237 | 8/20 | 0.46 |
| ▸ | MMP2 | P08253 | 7/20 | 0.46 |
| ▸ | MMP9 | P14780 | 6/20 | 0.46 |
| ▸ | MMP13 | P45452 | 6/20 | 0.46 |
| ▸ | MMP14 | P50281 | 5/20 | 0.46 |
| ▸ | MMP8 | P22894 | 5/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP16 | P51512 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763707 | 0.91 | LMNA (0.46) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL14843811 | 0.74 | CYP1A2 (0.39) | MMP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8596522 | 0.69 | MMP1 (0.47) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL4654488 | 0.67 | MMP1 (0.47) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL21358891 | 0.66 | MAPT (0.37) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7207157 | 0.65 | MMP13 (0.56) | MMP1MMP3MMP2MMP9MMP13 | |
| SCHEMBL6268904 | 0.65 | MMP1 (0.76) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7310778 | 0.64 | MMP13 (0.53) | MMP1MMP3MMP2MMP9MMP13 | |
| SCHEMBL1529244 | 0.63 | LMNA (0.48) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL49295 | 0.63 | MMP2 (0.65) | MMP1MMP3MMP7MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | claimed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | claimed |