Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11105483 | 0.79 | ADRA2A (0.37) | MEN1KMT2AKDM4ELMNAHTR1A | |
| SCHEMBL17746786 | 0.76 | POLB (0.44) | MAP4K4HTR1AGCK | |
| SCHEMBL558025 | 0.74 | LTA4H (0.42) | MEN1KMT2AALDH1A1KDM4EHTT | |
| SCHEMBL9684728 | 0.74 | MEN1 (0.46) | MEN1KMT2AMAP4K4ALDH1A1ESR1 | |
| SCHEMBL2044641 | 0.71 | MEN1 (0.59) | MEN1KMT2AMAP4K4ALDH1A1ESR1 | |
| SCHEMBL18984674 | 0.71 | MEN1 (0.59) | MEN1KMT2AMAP4K4ALDH1A1ESR1 | |
| SCHEMBL2389927 | 0.70 | HTR1A (0.55) | MEN1KMT2AALDH1A1ESR1KDM4E | |
| SCHEMBL30773497 | 0.70 | HTR1A (0.55) | MEN1KMT2AALDH1A1ESR1KDM4E | |
| SCHEMBL16541082 | 0.69 | MEN1 (0.53) | MEN1KMT2AMAP4K4ALDH1A1ESR1 | |
| SCHEMBL27606810 | 0.68 | MEN1 (0.47) | MEN1KMT2AMAP4K4ALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2736907-B1 | INDAZOLES | PFIZER LTD (GB) | 2015-10-07 | — | — | EP | disclosed |
| US-8895544-B2 | Indazoles | PFIZER LIMITED (GB) | 2014-11-25 | — | — | US | disclosed |
| EP-2736907-A1 | INDAZOLES | Pfizer Limited (GB) | 2014-06-04 | — | — | EP | disclosed |
| US-20140024634-A1 | INDAZOLES | PFIZER LIMITED (GB) | 2014-01-23 | — | — | US | disclosed |
| US-8575336-B2 | Indazoles | PFIZER LIMITED (GB) | 2013-11-05 | — | — | US | disclosed |
| WO-2013014567-A1 | INDAZOLES | PFIZER LIMITED (GB) | 2013-01-31 | — | — | WO | disclosed |
| US-20130029968-A1 | INDAZOLES | PFIZER LIMITED (GB) | 2013-01-31 | — | — | US | disclosed |
| US-6211190-B1 | Pyrimidine derivatives, process and intermediate products for their preparation and pesticides or fungicides containing these derivatives | BASF AKTIENGESELLSCHAFT (DE) | 2001-04-03 | — | — | US | disclosed |
| EP-0873305-B1 | AZINOOXIMETHERS, PROCESSES AND INTERMEDIATE PRODUCTS FOR MANUFACTURING SAME, AND THE USES THEREOF IN COMBATING HARMFUL FUNGI AND PESTS | BASF AG (DE) | 2001-03-28 | — | — | EP | disclosed |
| US-6200997-B1 | CYCLIZATION TO GIVE OXAZOLIDINEDIONES AND TRIAZOLIDINEDIONES | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-13 | — | — | US | disclosed |
| EP-0873307-B1 | CYANIMINO OXIME ETHERS, PROCESS AND INTERMEDIATES FOR THE PREPARATION AND USE THEREOF FOR THE CONTROL OF NOXIOUS FUNGI AND ANIMAL PESTS | BASF AG (DE) | 2000-05-31 | — | — | EP | disclosed |
| US-6063813-A | FUNGICIDES AND INSECTICIDES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-16 | — | — | US | disclosed |
| US-6043282-A | FUNGICIDES, PESTICIDES, INSECTICIDES, NEMATOCIDES, MITICIDES | BASF AKTIENGESELLSCHAFT (DE) | 2000-03-28 | — | — | US | disclosed |
| CN-1161687-A | Phenylacetic acid alkyl esters | BASF AG (DE) | 1997-10-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029968-A1 | INDAZOLES | CYP11B2, CYP11B1, IL33 | MEN1 4249/4885KMT2A 4073/4885MAP4K4 3559/4885 |
| US-20140024634-A1 | INDAZOLES | JAK1, JAK3, JAK2 | MEN1 4364/4885KMT2A 2168/4885MAP4K4 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.