Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 7/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8763029 | 0.97 | ELANE (0.40) | ELANEMMP1MMP3MMP2MMP7 | |
| SCHEMBL7384535 | 0.82 | ELANE (0.44) | ELANEMMP1MMP3MMP2MMP7 | |
| SCHEMBL8764118 | 0.81 | LTA4H (0.38) | MMP1MMP2MMP9ANPEPRNPEP | |
| SCHEMBL7402161 | 0.76 | MMP3 (0.48) | ELANEMMP1MMP3MMP2MMP7 | |
| SCHEMBL7402091 | 0.76 | ELANE (0.46) | ELANEMMP1MMP3MMP2MAOB | |
| SCHEMBL7397759 | 0.76 | MMP3 (0.49) | ELANEMMP1MMP3MMP2MMP7 | |
| SCHEMBL7403302 | 0.75 | MMP1 (0.48) | ELANEMMP1MMP3MMP2MMP7 | |
| SCHEMBL7405706 | 0.75 | ELANE (0.47) | ELANEMMP1MMP3MMP2MMP9 | |
| SCHEMBL7397719 | 0.73 | ELANE (0.44) | ELANEMMP1MMP3MMP2MMP7 | |
| SCHEMBL7593717 | 0.71 | ELANE (0.44) | ELANEMMP1MMP3MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |