Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 5/20 | 0.40 |
| ▸ | RXRA | P19793 | 4/20 | 0.40 |
| ▸ | RXRG | P48443 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969052 | 1.00 | GABRA1 (0.60) | GABRA1GABRB2POLBRXRBRXRA | |
| SCHEMBL548187 | 0.90 | GABRA1 (0.45) | GABRA1GABRB2RXRBRXRARXRG | |
| SCHEMBL15726901 | 0.89 | GABRA1 (0.50) | GABRA1GABRB2POLBRXRBRXRA | |
| SCHEMBL23113536 | 0.87 | GABRA1 (0.48) | GABRA1GABRB2POLBRXRBRXRA | |
| SCHEMBL20933032 | 0.87 | GABRA1 (0.48) | GABRA1GABRB2POLBRXRBRXRA | |
| SCHEMBL27358210 | 0.87 | GABRA1 (0.48) | GABRA1GABRB2POLBRXRBRXRA | |
| SCHEMBL18077869 | 0.87 | GABRA1 (0.48) | GABRA1GABRB2POLBRXRBRXRA | |
| SCHEMBL13278178 | 0.87 | GABRA1 (0.48) | GABRA1GABRB2POLBRXRBRXRA | |
| SCHEMBL16259555 | 0.83 | GABRA1 (0.44) | GABRA1GABRB2POLBRXRBRXRA | |
| SCHEMBL15132423 | 0.83 | GABRA1 (0.44) | GABRA1GABRB2POLBRXRBRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180064690-A1 | THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-08 | — | — | US | disclosed |
| US-9861618-B2 | Thiazoles as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-09 | — | — | US | disclosed |
| US-20160120850-A1 | THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
| EP-0675153-B1 | Process for the preparation of star-shaped polymers | SHELL INT RESEARCH (NL) | 2001-06-13 | — | — | EP | disclosed |
| EP-1099717-A2 | Star-shaped polymers | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 2001-05-16 | — | — | EP | disclosed |
| US-5458796-A | Synthesis of polyisobutylene star-branched polymers via living carbocationic polymerization | SHELL OIL COMPANY (US) | 1995-10-17 | — | — | US | disclosed |
| EP-0675153-A1 | Star-shaped polymers | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1995-10-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160120850-A1 | THIAZOLES AS MODULATORS OF RORyt | RORC, RORB, RORA | GABRA1 1980/4885GABRB2 2144/4885POLB 4767/4885 |
| US-20180064690-A1 | THIAZOLES AS MODULATORS OF RORyt | RORC, RORB, RORA | GABRA1 1893/4885GABRB2 2158/4885POLB 4784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.