Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL28801958 | 0.88 | TSHR (0.80) | TSHRSMN1; SMN2CYP2D6POLBMAPK1 | |
| Urea SCHEMBL7500665 | 0.88 | TSHR (0.80) | TSHRSMN1; SMN2CYP2D6POLBMAPK1 | |
| Hydrazine SCHEMBL11223582 | 0.87 | TSHR (0.89) | TSHRSMN1; SMN2CYP2D6POLBMAPK1 | |
| Hydroxyamine SCHEMBL9651752 | 0.87 | TSHR (0.89) | TSHRSMN1; SMN2CYP2D6POLBMAPK1 | |
| Hydrazine SCHEMBL5026988 | 0.87 | TSHR (0.89) | TSHRSMN1; SMN2CYP2D6POLBMAPK1 | |
| SCHEMBL597672 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2CYP2D6POLBALDH1A1 | |
| SCHEMBL3409457 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2CYP2D6POLBALDH1A1 | |
| SCHEMBL2509 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2CYP2D6POLBALDH1A1 | |
| Benzene SCHEMBL9751882 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2CYP2D6POLBALDH1A1 | |
| SCHEMBL30812783 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2CYP2D6POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114206334-B | Process for preparing aminopyrimidine compounds | 艾库斯生物科学有限公司 | 2025-01-07 | — | — | CN | claimed |
| EP-3980013-B1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES INC (US) | 2024-07-31 | — | — | EP | claimed |
| US-20220235031-A1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2022-07-28 | — | — | US | claimed |
| EP-3980013-A1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | Arcus Biosciences, Inc. (US) | 2022-04-13 | — | — | EP | claimed |
| CN-114206334-A | Process for preparing aminopyrimidine compounds | 艾库斯生物科学有限公司 | 2022-03-18 | — | — | CN | claimed |
| WO-2020247789-A1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. (US) | 2020-12-10 | — | — | WO | claimed |
| US-12630526-B2 | Processes for preparing aminopyrimidine compounds | ARCUS BIOSCIENCES, INC. (US) | 2026-05-19 | — | — | US | disclosed |
| CN-114206334-B | Process for preparing aminopyrimidine compounds | 艾库斯生物科学有限公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3980013-B1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES INC (US) | 2024-07-31 | — | — | EP | disclosed |
| US-20220235031-A1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2022-07-28 | — | — | US | disclosed |
| EP-3980013-A1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | Arcus Biosciences, Inc. (US) | 2022-04-13 | — | — | EP | disclosed |
| CN-114206334-A | Process for preparing aminopyrimidine compounds | 艾库斯生物科学有限公司 | 2022-03-18 | — | — | CN | disclosed |
| WO-2020247789-A1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. (US) | 2020-12-10 | — | — | WO | disclosed |
| CN-1491939-A | Hexa alkyl guanidine salt ion liquid and preparing process | 中国科学院长春应用化学研究所 | 2004-04-28 | — | — | CN | disclosed |
| EP-0890355-B1 | Hair treatment composition | KAO CORP (JP) | 2001-05-30 | — | — | EP | disclosed |
| US-6071504-A | GUANIDIUM SALT, AMINO-MODIFIED POLYSILOXANE; ODORLESS, SKIN SENSITIVITY | KAO CORPORATION (JP) | 2000-06-06 | — | — | US | disclosed |
| EP-0890355-A1 | Hair treatment composition | Kao Corporation (JP) | 1999-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12630526-B2 | Processes for preparing aminopyrimidine compounds | PAICS, CCNL2, UCK2 | TSHR 2838/4885SMN1; SMN2 583/4885CYP2D6 990/4885 |
| US-20220235031-A1 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS | DPYD, TYMP, DHPS | TSHR 4551/4885SMN1; SMN2 2084/4885CYP2D6 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.