Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049435 | 0.84 | SGMS2 (0.64) | SGMS2ALDH1A1KMT2AMAPTUSP2 | |
| SCHEMBL11794672 | 0.83 | KMT2A (0.64) | SGMS2ALDH1A1KMT2AMAPTUSP2 | |
| SCHEMBL2362772 | 0.82 | KMT2A (0.82) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL5852391 | 0.82 | SGMS2 (0.62) | SGMS2ALDH1A1KMT2AMAPTUSP2 | |
| SCHEMBL28158230 | 0.82 | SGMS2 (0.62) | SGMS2ALDH1A1KMT2AMAPTUSP2 | |
| SCHEMBL8052702 | 0.82 | KMT2A (0.63) | SGMS2ALDH1A1KMT2AMAPTUSP2 | |
| SCHEMBL17845885 | 0.81 | SGMS2 (0.60) | SGMS2ALDH1A1KMT2AMAPTUSP2 | |
| SCHEMBL437231 | 0.80 | ALDH1A1 (0.87) | ALDH1A1KMT2AMAPTMEN1HPGD | |
| SCHEMBL2564034 | 0.79 | CTSD (0.70) | SGMS2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL8458954 | 0.79 | SGMS2 (0.59) | SGMS2ALDH1A1KMT2AMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100484-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000003704-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-27 | — | — | WO | disclosed |