Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769539 | 0.83 | NPC1 (0.71) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6624870 | 0.81 | NPC1 (0.47) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL7115356 | 0.79 | ALDH1A1 (0.55) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL2395083 | 0.78 | ALDH1A1 (0.65) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL10726082 | 0.78 | ALDH1A1 (0.51) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL11599893 | 0.77 | ALDH1A1 (0.59) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL2499200 | 0.75 | MAPT (0.60) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6849659 | 0.75 | L3MBTL1 (0.58) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL7637081 | 0.75 | RAB9A (0.68) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL28507824 | 0.74 | HSD11B1 (0.60) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693488-B1 | An improved process for preparing 3-(4-aminoethoxy-benzoyl)benzo beta -thiophenes | LILLY CO ELI (US) | 2001-09-19 | — | — | EP | disclosed |
| US-5523416-A | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| US-5512684-A | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophenes | ELI LILLY AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0693488-A1 | An improved process for preparing 3-(4-aminoethoxy-benzoyl)benzo beta -thiophenes | ELI LILLY AND COMPANY (US) | 1996-01-24 | — | — | EP | disclosed |