Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Gamma-Aminobutyric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.48 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.48 |
| ▸ | GABBR2 known ✓ | O75899 | 1/20 | 0.48 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.48 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.48 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.48 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.48 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.48 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.48 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.48 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.48 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 1/20 | 0.48 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gamma-Aminobutyric Acid SCHEMBL587529 | 0.95 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL28332520 | 0.89 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL16177043 | 0.89 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL1685715 | 0.89 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL587045 | 0.89 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL28879139 | 0.89 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL9283723 | 0.89 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL377444 | 0.89 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL28332521 | 0.89 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL2768668 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010028886-A1 | Solid plaster-based cosmetic composition comprising a specific setting-kinetics modifier, preparation process and uses thereof | L'OREAL S.A. (FR) | 2001-10-11 | — | — | US | claimed |
| US-20010028886-A1 | Solid plaster-based cosmetic composition comprising a specific setting-kinetics modifier, preparation process and uses thereof | L'OREAL S.A. (FR) | 2001-10-11 | — | — | US | disclosed |
| US-20010028886-A1 | Solid plaster-based cosmetic composition comprising a specific setting-kinetics modifier, preparation process and uses thereof | L'OREAL S.A. (FR) | 2001-10-11 | — | — | US | disclosed |
| JP-2001199829-A | PLASTER BASE SOLID COSMETIC COMPOSITION CONTAINING SPECIFIC HARDENING RATE REGULATOR, METHOD FOR PREPARING THE SAME AND ITS USE | L'OREAL SA | 2001-07-24 | — | — | JP | disclosed |
| EP-1108414-A1 | A solid cosmetic composition containing plaster and a modifier of the setting kinetics, its preparation and its uses | L'OREAL (FR) | 2001-06-20 | — | — | EP | disclosed |