Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385316 | 0.86 | PTGS2 (0.69) | PTGS2PTGS1ABCB11ALDH1A1 | |
| Benzenesulfonamide SCHEMBL7192191 | 0.85 | PTGS2 (0.53) | PTGS2PTGS1ABCB11ALDH1A1 | |
| Benzenesulfonamide SCHEMBL7046453 | 0.84 | PTGS2 (0.65) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL7920280 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8640455 | 0.84 | PTGS2 (0.45) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL7932075 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8688532 | 0.79 | PTGS2 (0.57) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8692194 | 0.78 | PTGS2 (0.50) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8691591 | 0.78 | PTGS2 (0.57) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8692192 | 0.78 | PTGS2 (0.42) | PTGS2PTGS1ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001503395-A | — | — | 2001-03-13 | — | — | JP | claimed |
| EP-0932402-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA | G.D. SEARLE & CO. (US) | 1999-08-04 | — | — | EP | claimed |
| WO-1998016227-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA | G.D. SEARLE & CO. (US) | 1998-04-23 | — | — | WO | claimed |
| EP-0932402-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA | G.D. SEARLE & CO. (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016227-A9 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA | — | 1998-07-30 | — | — | WO | disclosed |
| WO-1998016227-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA | G.D. SEARLE & CO. (US) | 1998-04-23 | — | — | WO | disclosed |