SCHEMBL7775661

SCHEMBL7775661

CC(C)(C)C[C@](C(=O)O)(C(=O)[C@@H](N)CC(=O)O)N(C(=O)OCc1ccccc1)c1cccs1

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.33
CHRM2 P08172 2/20 0.33
CHRM1 P11229 2/20 0.33
CHRM3 P20309 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
SLC15A1 P46059 2/20 0.32
ABCB1 P08183 1/20 0.32
CASP3 P42574 1/20 0.32
CTSL P07711 1/20 0.32
CTSB P07858 1/20 0.32
CTSS P25774 1/20 0.32
CASP1 P29466 3/20 0.31
ALDH1A1 P00352 1/20 0.31
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8346336 0.85 CHRM2 (0.36) LTA4HCHRM2CHRM1CHRM3SMN1; SMN2
SCHEMBL7541791 0.79 L3MBTL1 (0.39) LTA4HCHRM2CHRM1CHRM3SMN1; SMN2
SCHEMBL10610709 0.71 LTA4H (0.38) LTA4HSMN1; SMN2SLC15A1ABCB1CASP1
SCHEMBL9301990 0.70 ABCB1 (0.40) LTA4HSMN1; SMN2SLC15A1ABCB1ALDH1A1
SCHEMBL11698202 0.67 LTA4H (0.40) LTA4HSMN1; SMN2SLC15A1ABCB1ALDH1A1
SCHEMBL7440888 0.66 ALDH1A1 (0.43) CHRM2CHRM1CHRM3SLC15A1ABCB1
SCHEMBL7451001 0.66 ALDH1A1 (0.43) CHRM2CHRM1CHRM3SLC15A1ABCB1
SCHEMBL7775655 0.66 LTA4H (0.33) LTA4HSMN1; SMN2SLC15A1ABCB1CTSL
SCHEMBL169622 0.64 LTA4H (0.54) LTA4HSMN1; SMN2SLC15A1ALDH1A1KMT2A
SCHEMBL27873595 0.64 LTA4H (0.54) LTA4HSMN1; SMN2SLC15A1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0837877-B1 L-ASPARTYL-L-THIENYLALANINE METHYL ESTERS, PROCESS FOR PRODUCING THEM AND THEIR USE AS SWEETENERS PHARMACON FORSCHUNG & BERATUNG GMBH (AT) 2001-08-16 EP disclosed
US-5929253-A L-aspartyl-L-thienylalanine methyl ester, process for its preparation and use as sweetener PHARMACON FORSCHUNG UND BERATUNG GMBH (AT) 1999-07-27 US disclosed