Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | ESRRB | O95718 | 1/20 | 0.43 |
| ▸ | ESRRA | P11474 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27993217 | 0.88 | ALOX15 (0.52) | ESR1ESR2ABL1ABCB1BCR | |
| SCHEMBL1026674 | 0.86 | ALOX5 (0.59) | ESR1ESR2HSD17B10ABL1ABCB1 | |
| SCHEMBL9440083 | 0.85 | ESR1 (0.46) | ESR1ESR2HSD17B10ALOX15ALOX5 | |
| SCHEMBL7777345 | 0.82 | ESR2 (0.57) | ESR1ESR2HSD17B10ABL1ABCB1 | |
| SCHEMBL6638817 | 0.81 | HSD17B10 (0.50) | ESR1ESR2HSD17B10ABL1ABCB1 | |
| SCHEMBL5859637 | 0.80 | HSD17B1 (0.54) | ESR1ESR2HSD17B10PELI1HSD17B1 | |
| SCHEMBL7778332 | 0.78 | ESR2 (0.57) | ESR1ESR2HSD17B10ABL1ABCB1 | |
| SCHEMBL11288181 | 0.76 | ALDH1A1 (0.65) | ESR1ESR2HSD17B10ABL1ABCB1 | |
| SCHEMBL2770537 | 0.75 | PELI1 (0.57) | ESR1ESR2HSD17B10ABL1ABCB1 | |
| SCHEMBL28542905 | 0.75 | S100A4 (0.48) | ALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121125-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2001-08-08 | — | — | EP | claimed |
| WO-2000021535-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2000-04-20 | — | — | WO | claimed |
| EP-1121125-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000021535-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2000-04-20 | — | — | WO | disclosed |