Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.50 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.50 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18956515 | 0.92 | HTT (0.57) | HPGDALOX15TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL18956313 | 0.91 | PLA2G4A (0.59) | HPGDALOX15TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL25381692 | 0.86 | KDM4E (0.56) | HPGDALOX15TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL25381690 | 0.82 | ALDH1A1 (0.58) | HPGDALOX15TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL27785098 | 0.81 | MEN1 (0.52) | HPGDALOX15TDP1CYP2C19SMN1; SMN2 | |
| SCHEMBL1458948 | 0.80 | PKM (0.67) | HPGDCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL25382013 | 0.79 | SMN1; SMN2 (0.49) | HPGDALOX15TDP1CYP1A2CYP3A4 | |
| SCHEMBL25383792 | 0.79 | SLC6A3 (0.47) | HPGDALOX15TDP1CYP1A2CYP3A4 | |
| SCHEMBL4067173 | 0.78 | HPGD (1.00) | HPGDALOX15TDP1CYP1A2CYP3A4 | |
| SCHEMBL1691553 | 0.78 | CYP2C19 (0.49) | CYP3A4CYP2C9CYP2C19L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129084-A2 | PPAR GAMMA LIGANDS | GLAXO GROUP LIMITED (GB) | 2001-09-05 | — | — | EP | claimed |
| WO-2000027832-A2 | THIAZOLE DERIVATIVES AS PPAR GAMMA LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-05-18 | — | — | WO | claimed |
| EP-1129084-A2 | PPAR GAMMA LIGANDS | GLAXO GROUP LIMITED (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027832-A2 | THIAZOLE DERIVATIVES AS PPAR GAMMA LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-05-18 | — | — | WO | disclosed |