Sugi Predict

Sugi Predict / Compounds / SCHEMBL777846

SCHEMBL777846

SCHEMBL777846

Cc1ccc(C(=O)SSC(=O)c2ccc(C)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 0.59
▸ CES2 O00748 3/20 0.59
▸ CES1 P23141 3/20 0.59
▸ LMNA P02545 3/20 0.59
▸ SMN1; SMN2 Q16637 3/20 0.56
▸ KMT2A Q03164 4/20 0.52
▸ HTT P42858 3/20 0.52
▸ NPSR1 Q6W5P4 3/20 0.52
▸ TDP1 Q9NUW8 3/20 0.52
▸ PKM P14618 2/20 0.52
▸ ATM Q13315 2/20 0.52
▸ HPGD P15428 2/20 0.52
▸ MEN1 O00255 2/20 0.52
▸ NLRP1 Q9C000 1/20 0.52
▸ GAA P10253 1/20 0.52
▸ NTSR1 P30989 1/20 0.52
▸ NPC1 O15118 4/20 0.50
▸ RAB9A P51151 4/20 0.50
▸ SRD5A2 P31213 1/20 0.50
▸ HDAC1 Q13547 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL776222 0.88 ALDH1A1 (0.52) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL775535 0.84 ALDH1A1 (0.59) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL775692 0.83 ALDH1A1 (0.46) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL775142 0.82 ALDH1A1 (0.56) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL27498417 0.80 ALDH1A1 (0.54) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL1478848 0.80 ALDH1A1 (0.54) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL2831004 0.80 ALDH1A1 (0.54) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL17422144 0.80 ALDH1A1 (0.54) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL22195311 0.80 CA2 (0.50) ALDH1A1CES2CES1LMNASMN1; SMN2
SCHEMBL775689 0.80 CES2 (0.52) ALDH1A1CES2CES1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12264174-B2 Process for preparing imetelstat GERON CORPORATION (US) 2025-04-01 — — US claimed
US-20240262854-A1 Process for Preparing Imetelstat BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT (GB) 2024-08-08 — — US claimed
CN-110891961-B Improved process for the preparation of imaelstat 美国杰龙生物医药公司 2023-06-30 — — CN claimed
US-11332489-B2 Process for preparing imetelstat GERON CORPORATION (US) 2022-05-17 — — US claimed
EP-3652187-B1 IMPROVED PROCESS FOR PREPARING IMETELSTAT GERON CORP (US) 2021-09-15 — — EP claimed
CN-110891961-A Improved process for the preparation of isomestat (imetelstat) 美国杰龙生物医药公司 2020-03-17 — — CN claimed
US-12264174-B2 Process for preparing imetelstat GERON CORPORATION (US) 2025-04-01 — — US disclosed
US-20240262854-A1 Process for Preparing Imetelstat BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT (GB) 2024-08-08 — — US disclosed
US-20240199672-A1 Process for Preparing Imetelstat BIOPHARMA CREDIT PLC [COLLATERAL AGENT] (GB) 2024-06-20 — — US disclosed
CN-110891961-B Improved process for the preparation of imaelstat 美国杰龙生物医药公司 2023-06-30 — — CN disclosed
CN-115911573-A Nonaqueous electrolyte solution for secondary battery and nonaqueous electrolyte secondary battery using same 三菱化学株式会社 2023-04-04 — — CN disclosed
US-20230070069-A1 Process for Preparing Imetelstat GERON CORPORATION 2023-03-09 — — US disclosed
US-11332489-B2 Process for preparing imetelstat GERON CORPORATION (US) 2022-05-17 — — US disclosed
US-9252457-B2 Non-aqueous liquid electrolyte and non-aqueous liquid electrolyte secondary battery MITSUBISHI CHEMICAL CORPORATION (JP) 2016-02-02 — — US disclosed
US-20120177988-A1 NON-AQUEOUS LIQUID ELECTROLYTE AND NON-AQUEOUS LIQUID ELECTROLYTE SECONDARY BATTERY MITSUBISHI CHEMICAL CORPORATION (JP) 2012-07-12 — — US disclosed
US-20120070731-A1 NON-AQUEOUS LIQUID ELECTROLYTE AND NON-AQUEOUS LIQUID ELECTROLYTE SECONDARY BATTERY MITSUBISHI CHEMICAL CORPORATION (JP) 2012-03-22 — — US disclosed
US-5847061-A Process for producing polymers having terminal functional group which may be protected KURARAY CO., LTD. (JP) 1998-12-08 — — US disclosed
EP-0704460-B1 PROCESS FOR PRODUCING POLYMER TERMINATED WITH OPTIONALLY PROTECTED FUNCTIONAL GROUP KURARAY CO (JP) 1998-11-04 — — EP disclosed
EP-0704460-A1 PROCESS FOR PRODUCING POLYMER TERMINATED WITH OPTIONALLY PROTECTED FUNCTIONAL GROUP KURARAY CO., LTD. (JP) 1996-04-03 — — EP disclosed
US-4245033-A AN ORGANIC SILVER SALT, A HALIDE AND A SULFUR COMPOUND EXPOSED TO FORM A SILVER IMAGE OF HIGH CONTRAST AND STABILITY CANON KABUSHIKI KAISHA (JP) 1981-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230070069-A1 Process for Preparing Imetelstat TERT, RNGTT, TRMT1L ALDH1A1 2272/4885CES2 3750/4885CES1 2380/4885
US-11332489-B2 Process for preparing imetelstat RNGTT, TERT, TRMT1L ALDH1A1 2336/4885CES2 3546/4885CES1 2345/4885
US-20240262854-A1 Process for Preparing Imetelstat TERT, RNGTT, TRMT1L ALDH1A1 2272/4885CES2 3750/4885CES1 2380/4885
US-12264174-B2 Process for preparing imetelstat TERT, RNGTT, TRMT1L ALDH1A1 2272/4885CES2 3750/4885CES1 2380/4885
US-20240199672-A1 Process for Preparing Imetelstat TERT, RNGTT, TRMT1L ALDH1A1 2272/4885CES2 3750/4885CES1 2380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.