Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 5/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7778742 | 0.84 | CTSV (0.42) | CTSVCTSLKIF11THRBHTT | |
| SCHEMBL7782053 | 0.84 | CTSV (0.43) | CTSVCTSLHTTALDH1A1 | |
| SCHEMBL7781279 | 0.83 | KIF11 (0.39) | CTSVCTSLKIF11THRBHTT | |
| SCHEMBL6911048 | 0.82 | ADRB3 (0.49) | ADRB2ADRB3ADRA1A | |
| SCHEMBL7781344 | 0.80 | ADRB2 (0.40) | CTSVCTSLKIF11THRBHTT | |
| SCHEMBL7778926 | 0.79 | KIF11 (0.41) | CTSVCTSLKIF11THRBHTT | |
| SCHEMBL7779190 | 0.76 | CTSV (0.45) | CTSVCTSLMAOAADRA1A | |
| SCHEMBL6912018 | 0.74 | ALOX15 (0.54) | CTSVCTSLKDM4EADRB2ADRB3 | |
| SCHEMBL6912318 | 0.74 | ALOX15 (0.54) | CTSVCTSLKDM4EADRB2ADRB3 | |
| SCHEMBL6905931 | 0.74 | ALOX15 (0.54) | CTSVCTSLKDM4EADRB2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1128845-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTDIABETIC AGENT | SMITHKLINE BEECHAM PLC (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027434-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTIDIABETIC AGENT | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-18 | — | — | WO | disclosed |