Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 10/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7778742 | 0.88 | CTSV (0.42) | KIF11ADRB2NR1I2CTSVCTSL | |
| SCHEMBL7781344 | 0.83 | ADRB2 (0.40) | KIF11ADRB2NR1I2CTSVCTSL | |
| SCHEMBL6913351 | 0.83 | ADRB2 (0.54) | ADRB2NR1I2ADRB1ADRB3KDM4E | |
| SCHEMBL7778756 | 0.83 | CTSV (0.38) | KIF11ADRB2CTSVCTSLADRB3 | |
| Hydrochloric Acid SCHEMBL7108122 | 0.82 | ADRB2 (0.53) | ADRB2NR1I2ADRB1ADRB3KDM4E | |
| SCHEMBL7782053 | 0.79 | CTSV (0.43) | CTSVCTSLHTTDRD2DRD4 | |
| SCHEMBL7778926 | 0.78 | KIF11 (0.41) | KIF11ADRB2CTSVCTSLTHRB | |
| SCHEMBL7779190 | 0.77 | CTSV (0.45) | CTSVCTSLHTR1AADRA1DADRA1A | |
| SCHEMBL6916301 | 0.71 | ADRB2 (0.46) | ADRB2ADRB1ADRB3DRD2DRD4 | |
| SCHEMBL12886607 | 0.71 | MAOA (0.57) | KIF11NR1I2CTSVCTSLTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1128845-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTDIABETIC AGENT | SMITHKLINE BEECHAM PLC (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027434-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTIDIABETIC AGENT | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-18 | — | — | WO | disclosed |