Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | CASR | P41180 | 3/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787455 | 0.92 | CYP2D6 (0.39) | CA1CA2ACHECASRCHRM4 | |
| SCHEMBL7787479 | 0.86 | MEN1 (0.39) | CA1CA2ACHECASRMEN1 | |
| SCHEMBL7784903 | 0.83 | ALDH1A1 (0.37) | CA1CA2ACHECASRMAPT | |
| SCHEMBL7780524 | 0.81 | SMN1; SMN2 (0.43) | MAPTMEN1KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL7780319 | 0.81 | CYP2D6 (0.40) | CA1CA2ACHEMAPTGAA | |
| SCHEMBL7787498 | 0.78 | CA1 (0.34) | CA1CA2ACHECASRCHRM4 | |
| SCHEMBL7780785 | 0.78 | TDP1 (0.43) | CA1CA2ACHECASRMAPT | |
| SCHEMBL7801984 | 0.77 | CXCR2 (0.36) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7780419 | 0.77 | KRAS (0.43) | CA1CA2ACHECASRGAA | |
| SCHEMBL7780509 | 0.77 | MAPKAPK2 (0.34) | MEN1KMT2ACYP2D6ALDH1A1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |