Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CASR | P41180 | 8/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | PRKCG | P05129 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.36 |
| ▸ | PRKX | P51817 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787455 | 0.89 | CYP2D6 (0.39) | MEN1KMT2ACASRCYP2D6MAPK1 | |
| SCHEMBL7780363 | 0.86 | CA1 (0.34) | MEN1KMT2ACASRCYP2D6RPS6KB1 | |
| SCHEMBL7784937 | 0.85 | KRAS (0.37) | MEN1KMT2ACASRPFKFB3CYP2D6 | |
| SCHEMBL7785507 | 0.83 | MAPT (0.40) | MEN1KMT2ACYP2D6MAPK1ALDH1A1 | |
| SCHEMBL7780419 | 0.81 | KRAS (0.43) | KMT2ACASRALDH1A1CYP2C9CA1 | |
| SCHEMBL7784903 | 0.81 | ALDH1A1 (0.37) | MEN1KMT2ACASRMAPK1ALDH1A1 | |
| SCHEMBL7780432 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2ACASRALDH1A1CYP3A4 | |
| SCHEMBL7780640 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2ACASRALDH1A1CYP3A4 | |
| SCHEMBL7785127 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2ACASRALDH1A1CYP3A4 | |
| SCHEMBL7801958 | 0.79 | MEN1 (0.39) | MEN1KMT2APRKACAAKT1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |