Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 1/20 | 0.62 |
| ▸ | DRD5 | P21918 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10396301 | 0.99 | DRD1 (0.61) | DRD1DRD5SIGMAR1HTR1AKDM4E | |
| SCHEMBL10397237 | 0.81 | DRD1 (0.54) | DRD1DRD5SIGMAR1HTR1AMEN1 | |
| SCHEMBL17792374 | 0.81 | SIGMAR1 (0.60) | SIGMAR1HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL10396300 | 0.80 | HTR1A (0.60) | DRD1DRD5HTR1A | |
| SCHEMBL17517486 | 0.80 | SIGMAR1 (0.68) | SIGMAR1HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL24122147 | 0.80 | SIGMAR1 (0.58) | DRD1DRD5SIGMAR1HTR1AKDM4E | |
| SCHEMBL22528276 | 0.80 | SIGMAR1 (0.58) | DRD1DRD5SIGMAR1HTR1AKDM4E | |
| SCHEMBL29411058 | 0.79 | SIGMAR1 (0.75) | SIGMAR1HTR1AGRIN2B | |
| SCHEMBL10397351 | 0.78 | PRMT5 (0.56) | DRD1DRD5HTR1AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL16335548 | 0.78 | SIGMAR1 (0.73) | SIGMAR1HTR1AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1066185-A | — | — | None | — | — | JP | disclosed |
| EP-1140838-A1 | 1, 4-PIPERAZINE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| US-20010014680-A1 | 1,4-piperazine derivatives | WYETH | 2001-08-16 | — | — | US | disclosed |
| US-6255302-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-03 | — | — | US | disclosed |
| WO-2000035878-A1 | 1,4-PIPERAZINE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
| US-4977159-A | HYPOTENSIVE AGENTS | SYNTHELABO (FR) | 1990-12-11 | — | — | US | disclosed |
| US-4977159-A | HYPOTENSIVE AGENTS | SYNTHELABO (FR) | 1990-12-11 | — | — | US | disclosed |
| JP-S6466185-A | 2-((4-PIPERIDYL)METHYL)-1,2,3,4-TETRAHYDRO-9H- PYRIDO(3,4-B)INDOLE DERIVATIVE, MANUFACTURE AND USE FOR REMEDY | SYNTHELABO | 1989-03-13 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010014680-A1 | 1,4-piperazine derivatives | ADH1A, ADH1C, SNCA | DRD1 6/4885DRD5 63/4885SIGMAR1 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.