SCHEMBL7783973

SCHEMBL7783973

Oc1ccc(-n2nc3ccc(F)cc3n2)c(O)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AMY1A P0DUB6 1/20 0.42
NPC1 O15118 4/20 0.41
RAB9A P51151 4/20 0.41
ESR1 P03372 3/20 0.40
KDM4E B2RXH2 1/20 0.39
LMNA P02545 1/20 0.37
PDK1 Q15118 3/20 0.36
PDK2 Q15119 3/20 0.36
PDK3 Q15120 3/20 0.36
PDK4 Q16654 3/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
ESR2 Q92731 1/20 0.35
APP P05067 1/20 0.35
SULT1A1 P50225 1/20 0.35
CASP3 P42574 1/20 0.35
SENP8 Q96LD8 1/20 0.35
SENP7 Q9BQF6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29602456 1.00 AMY1A (0.42) AMY1ANPC1RAB9AESR1KDM4E
SCHEMBL17201891 0.88 NPC1 (0.42) AMY1ANPC1RAB9AESR1KDM4E
SCHEMBL28556638 0.83 NPC1 (0.40) AMY1ANPC1RAB9AESR1LMNA
SCHEMBL45835 0.81 NPC1 (0.54) NPC1RAB9AKDM4ELMNAMEN1
SCHEMBL5834727 0.81 ALOX5 (0.41) NPC1RAB9AKDM4ELMNAMEN1
SCHEMBL9010899 0.81 NPC1 (0.55) NPC1RAB9AESR1KDM4ELMNA
SCHEMBL2801293 0.81 NPC1 (0.37) AMY1ANPC1RAB9AKDM4ELMNA
SCHEMBL30383298 0.81 MAPT (0.41) NPC1RAB9AESR1KDM4ELMNA
SCHEMBL2800533 0.81 MAPT (0.41) NPC1RAB9AESR1KDM4ELMNA
SCHEMBL7785479 0.81 NPC1 (0.37) AMY1ANPC1RAB9AESR1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12504568-B2 Photochromic-dichroic articles TRANSITIONS OPTICAL, LTD. (IE) 2025-12-23 US disclosed
EP-4244305-B1 PHOTOCHROMIC-DICHROIC ARTICLES TRANSITIONS OPTICAL LTD (IE) 2025-05-21 EP disclosed
US-20230400616-A1 Photochromic-Dichroic Articles TRANSITIONS OPTICAL, LTD. (IE) 2023-12-14 US disclosed
CN-116391009-A Photochromic-dichroic articles 光学转变有限公司 2023-07-04 CN disclosed
EP-1144391-A1 ONE-POT PROCESS FOR THE PREPARATION OF 5-SULFONYL-SUBSTITUTED BENZOTRIAZOLES Ciba SC Holding AG (CH) 2001-10-17 EP disclosed
WO-2000043376-A1 ONE-POT PROCESS FOR THE PREPARATION OF 5-SULFONYL-SUBSTITUTED BENZOTRIAZOLES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-07-27 WO disclosed
US-6040455-A REACTING A HALOBENZOTRIAZOLE COMPOUND WITH ALIPHATIC, PHENYLALKYL OR ARYL MERCAPTAN COMPOUND TO FORM 5-THIO SUBSTITUTED BENZOTRIAZOLE, OXIDIZING WITH HYDROGEN PEROXIDE TO FOR 5-SULFONE SUBSTITUED BENZOTRIAZOLE COMPOUND CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-03-21 US disclosed