SCHEMBL7784779

SCHEMBL7784779

CCOP(=O)(OCC)C(Nc1ncc(Cl)cc1Cl)P(=O)(OCC)OCC

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 2/20 0.43
L3MBTL1 Q9Y468 6/20 0.39
TDP1 Q9NUW8 3/20 0.39
TSHR P16473 1/20 0.39
MAPT P10636 2/20 0.36
GAA P10253 1/20 0.36
GRM5 P41594 1/20 0.36
POLB P06746 1/20 0.36
CTDSP1 Q9GZU7 1/20 0.36
MEN1 O00255 1/20 0.36
HTT P42858 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD17B10 Q99714 1/20 0.36
LMNA P02545 1/20 0.36
THRB P10828 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7790434 0.83 L3MBTL1 (0.53) L3MBTL1TDP1MAPTGAAPOLB
SCHEMBL7790446 0.76 FDPS (0.55) CRHR1
SCHEMBL7794298 0.76 FDPS (0.60) L3MBTL1TDP1TSHRMAPTHTT
SCHEMBL8407752 0.73 L3MBTL1 (0.40) CRHR1L3MBTL1TDP1MAPTGAA
SCHEMBL7793613 0.70 L3MBTL1 (0.45) L3MBTL1MAPTPOLBMEN1KMT2A
SCHEMBL8007654 0.70 CRHR1 (0.48) CRHR1TDP1MAPTGAAPOLB
SCHEMBL8166679 0.68 FDPS (0.62) L3MBTL1TSHRMAPTGAAPOLB
SCHEMBL12909531 0.68 KMT2A (0.50) CRHR1L3MBTL1TDP1MAPTGAA
SCHEMBL5359859 0.67 TSHR (0.42) TSHRMAPTGAAPOLBMEN1
SCHEMBL7790467 0.67 POLB (0.40) GAAPOLBMEN1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0762883-B1 PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT LEIRAS OY (FI) 2001-11-14 EP claimed
EP-0762883-A1 PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT LEIRAS OY (FI) 1997-03-19 EP claimed
WO-1995033466-A1 PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT LEIRAS OY (FI) 1995-12-14 WO claimed
EP-0762883-B1 PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT LEIRAS OY (FI) 2001-11-14 EP disclosed
US-6083938-A TREATING BONE DISEASES SELECTED FROM THE GROUP CONSISTING OF OSTEOLYTIC BONE DISEASES DUE TO MALIGNANCY, PAGET'S DISEASE AND PRIMARY AND SECONDARY OSTEOPOROSIS LEIRAS OY (FI) 2000-07-04 US disclosed
US-5866556-A BONE DISORDERS LEIRAS OY (FI) 1999-02-02 US disclosed
EP-0762883-A1 PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT LEIRAS OY (FI) 1997-03-19 EP disclosed
WO-1995033466-A1 PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT LEIRAS OY (FI) 1995-12-14 WO disclosed