Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7790669 | 0.76 | FDPS (0.54) | POLBRAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL8166679 | 0.76 | FDPS (0.62) | POLBRAB9ANPC1ALOX12KMT2A | |
| SCHEMBL5360999 | 0.75 | FDPS (0.58) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL5155756 | 0.75 | FDPS (0.47) | POLBRAB9ANPC1HTT | |
| SCHEMBL7784728 | 0.72 | NPC1 (0.49) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5366533 | 0.71 | FDPS (0.59) | POLBRAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL8166911 | 0.71 | FDPS (0.40) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7793613 | 0.70 | L3MBTL1 (0.45) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7794298 | 0.70 | FDPS (0.60) | RAB9ANPC1ALDH1A1LMNAHTT | |
| SCHEMBL2037028 | 0.70 | POLB (0.47) | POLBRAB9ANPC1ALOX12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762883-B1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 2001-11-14 | — | — | EP | claimed |
| EP-0762883-A1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 1997-03-19 | — | — | EP | claimed |
| WO-1995033466-A1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 1995-12-14 | — | — | WO | claimed |
| US-5866556-A | BONE DISORDERS | LEIRAS OY (FI) | 1999-02-02 | — | — | US | disclosed |