Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.53 |
| ▸ | EDNRB | P24530 | 9/20 | 0.53 |
| ▸ | DHPS | P49366 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1009078 | 0.89 | EDNRA (0.66) | EDNRAEDNRBDHPS | |
| SCHEMBL1008387 | 0.87 | EDNRA (0.53) | EDNRAEDNRBDHPS | |
| SCHEMBL7793953 | 0.87 | EDNRA (0.64) | EDNRAEDNRBDHPS | |
| SCHEMBL2489314 | 0.87 | EDNRA (0.53) | EDNRAEDNRBDHPS | |
| SCHEMBL8007885 | 0.86 | EDNRA (0.55) | EDNRAEDNRBDHPS | |
| SCHEMBL2490097 | 0.85 | EDNRA (0.62) | EDNRAEDNRBDHPS | |
| SCHEMBL1009939 | 0.85 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL10066030 | 0.85 | EDNRA (0.52) | EDNRAEDNRBDHPS | |
| SCHEMBL2487362 | 0.85 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL29770374 | 0.85 | DHPS (0.58) | EDNRAEDNRBDHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256371-A1 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND ITS INTERMEDIATES THEREOF | GLENMARK (IN) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256371-A1 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND ITS INTERMEDIATES THEREOF | PTGIS, EDNRB, CYP11B2 | EDNRA 6/4885EDNRB 2/4885DHPS 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.