Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7788066 | 0.77 | LMNA (0.42) | ALDH1A1LMNACYP17A1CYP19A1P2RX7 | |
| Hydrochloric Acid SCHEMBL9065650 | 0.72 | P2RX7 (0.42) | ALDH1A1LMNACYP17A1CYP19A1P2RX7 | |
| Hydrochloric Acid SCHEMBL2114600 | 0.71 | ALDH1A1 (0.38) | ALDH1A1LMNACYP17A1CYP19A1P2RX7 | |
| SCHEMBL3320998 | 0.60 | HPGD (0.75) | ALDH1A1LMNACYP17A1CYP19A1HPGD | |
| SCHEMBL23220249 | 0.60 | THRB (0.63) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2841738 | 0.60 | THRB (0.63) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7702205 | 0.60 | ALDH1A1 (0.59) | ALDH1A1LMNACYP17A1CYP19A1HPGD | |
| SCHEMBL13333022 | 0.59 | ALDH1A1 (0.55) | ALDH1A1CYP17A1CYP19A1HPGDHSD11B1 | |
| SCHEMBL7707848 | 0.59 | CNR2 (0.65) | ALDH1A1LMNAP2RX7CNR2 | |
| Hydrochloric Acid SCHEMBL7044171 | 0.59 | HTT (0.50) | ALDH1A1LMNACYP17A1CYP19A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5539056-A | POLYPROPYLENE BLEND OF HIGH AND LOW MOLECULAR WEIGHT POLYMERS FOR HIGH STRENGTH FLEXIBLE HOSES, TUBES, AUTOMOBILE BUMPERS, GASKETS OR MEDICAL DEVICES | EXXON CHEMICAL PATENTS INC. (US) | 1996-07-23 | — | — | US | disclosed |