SCHEMBL7788925

SCHEMBL7788925

O=S(=O)(Oc1ccc2ccc3ccccc3c2c1-c1cccc2ccc3ccccc3c12)C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.40
ALDH1A1 P00352 3/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
DRD2 P14416 4/20 0.37
DNMT1 P26358 1/20 0.35
AHR P35869 3/20 0.33
KDM4E B2RXH2 3/20 0.33
HPGD P15428 2/20 0.33
CES1 P23141 1/20 0.33
SLC2A1 P11166 1/20 0.32
CDK4 P11802 1/20 0.32
CCND1 P24385 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7799372 0.90 MAPT (0.38) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL3811084 0.85 MAPT (0.43) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL17080387 0.83 FABP1 (0.40) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL7788933 0.83 G6PD (0.37) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL29560409 0.83 MAPT (0.49) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL635407 0.83 MAPT (0.49) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL31338576 0.82 ALDH1A1 (0.39) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL7795700 0.82 DRD2 (0.44) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL27796343 0.80 MAPT (0.63) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL23581680 0.79 MAPT (0.41) MAPTALDH1A1MEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0731105-B1 Optically active tertiary phosphine compounds, transition metal complexes comprising the same as ligands and process for preparing optically active organic silicon compounds using said transition metal complexes SUMITOMO CHEMICAL CO (JP) 2001-12-05 EP disclosed
US-5621129-A Optically active tertiary phosphine compound, transition metal complex comprising the same as ligand and process for preparing optically active organic silicon compound using said transition metal complex SUMITOMO CHEMICAL CO., LTD. (JP) 1997-04-15 US disclosed
EP-0731105-A1 Optically active tertiary phosphine compounds, transition metal complexes comprising the same as ligands and process for preparing optically active organic silicon compounds using said transition metal complexes SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-09-11 EP disclosed