Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA6 | P23280 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21877452 | 0.90 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL10102360 | 0.88 | ALOX5 (0.44) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL7789620 | 0.83 | MEN1 (0.45) | ALDH1A1MAPTKDM4ESMN1; SMN2ALOX5 | |
| SCHEMBL7784188 | 0.80 | TRPM4 (0.44) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL10106883 | 0.75 | ACHE (0.51) | MAPTKDM4ESMN1; SMN2MAPK1CYP2D6 | |
| SCHEMBL7497292 | 0.73 | AR (0.48) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL12952508 | 0.73 | ALOX5 (0.44) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL29120671 | 0.72 | ALOX5 (0.53) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL3380386 | 0.71 | KDM4E (0.49) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL13880266 | 0.71 | DRD2 (0.46) | ALDH1A1MAPTKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042312-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHO[2,1-b]PYRANS | TRANSITIONS OPTICAL INC (US) | 2001-11-07 | — | — | EP | claimed |
| EP-1042312-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHO[2,1-b]PYRANS | TRANSITIONS OPTICAL INC (US) | 2001-11-07 | — | — | EP | disclosed |
| US-5869658-A | POLYMERIC ORGANIC HOST MATERIALS THAT CONTAIN OR THAT ARE COATED WITH THE NOVEL NAPHTHOPYRAN COMPOUNDS, LENSES | PPG INDUSTRIES, INC. (US) | 1999-02-09 | — | — | US | disclosed |