Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 8/20 | 0.58 |
| ▸ | METAP1 | P53582 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | CCR1 | P32246 | 2/20 | 0.55 |
| ▸ | CCR5 | P51681 | 2/20 | 0.55 |
| ▸ | CCR8 | P51685 | 2/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | ALPG | P10696 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Mercaptobenzimidazole SCHEMBL7794586 | 0.88 | CCR1 (0.60) | METAP2METAP1SMN1; SMN2LMNANPC1 | |
| 2-Mercaptobenzimidazole SCHEMBL7793857 | 0.82 | CBFB (0.53) | METAP2METAP1SMN1; SMN2LMNANPC1 | |
| SCHEMBL4808230 | 0.81 | METAP2 (0.81) | METAP2METAP1SMN1; SMN2LMNANPC1 | |
| 2-Mercaptobenzimidazole SCHEMBL29020463 | 0.81 | RAB9A (0.51) | METAP2METAP1SMN1; SMN2LMNANPC1 | |
| 2-Mercaptobenzimidazole SCHEMBL2277594 | 0.80 | RAB9A (0.50) | METAP2METAP1SMN1; SMN2LMNANPC1 | |
| Hydrochloric Acid SCHEMBL4812284 | 0.80 | METAP2 (0.79) | METAP2METAP1SMN1; SMN2LMNANPC1 | |
| 2-Mercaptobenzimidazole SCHEMBL29368206 | 0.80 | ALDH1A1 (0.60) | SMN1; SMN2NPC1RAB9AHPGDPKM | |
| 2-Mercaptobenzimidazole SCHEMBL36857 | 0.80 | ALDH1A1 (0.60) | SMN1; SMN2NPC1RAB9AHPGDPKM | |
| 2-Mercaptobenzimidazole SCHEMBL4911436 | 0.78 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9AHPGDPKM | |
| 2-Mercaptobenzimidazole SCHEMBL11207938 | 0.78 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9AHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155025-A1 | PLATINUM (II) COMPOUNDS | ISIS INNOVATION LIMITED (GB) | 2001-11-21 | — | — | EP | claimed |
| WO-2000050431-A1 | PLATINUM (II) COMPOUNDS | ISIS INNOVATION LIMITED (GB) | 2000-08-31 | — | — | WO | claimed |
| EP-1155025-A1 | PLATINUM (II) COMPOUNDS | ISIS INNOVATION LIMITED (GB) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050431-A1 | PLATINUM (II) COMPOUNDS | ISIS INNOVATION LIMITED (GB) | 2000-08-31 | — | — | WO | disclosed |