Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795399 | 0.79 | ESR2 (0.42) | GRIA2GRIA4ALDH1A1TSHRKMT2A | |
| SCHEMBL1232755 | 0.79 | ALDH1A1 (0.45) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL7791085 | 0.78 | ESR2 (0.44) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL7791554 | 0.77 | ESR2 (0.37) | RAB9ANPC1GRIA2GRIA4TSHR | |
| SCHEMBL4618290 | 0.75 | ALDH1A1 (0.56) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL7791522 | 0.74 | NAAA (0.33) | RAB9ANPC1GRIA2GRIA4 | |
| SCHEMBL20607703 | 0.72 | XDH (0.40) | RAB9ANPC1ALDH1A1TSHRKDM4E | |
| SCHEMBL7791778 | 0.71 | TSHR (0.46) | TDP1GRIA2GRIA4ALDH1A1TSHR | |
| SCHEMBL9025920 | 0.71 | FFAR1 (0.57) | GRIA2GRIA4ALDH1A1ESR2FFAR1 | |
| SCHEMBL24947662 | 0.71 | IMPDH2 (0.45) | RAB9ANPC1CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5672596-A | ANIMAL GROWTH CONTROLLERS | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0659179-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0659179-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-06-28 | — | — | EP | disclosed |
| EP-0583783-B1 | Synthetic aluminosilicates and their use as heterogen rearrangement catalysts | WACKER CHEMIE GMBH (DE) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| EP-0583783-A1 | Synthetic aluminosilicates and their use as heterogen rearrangement catalysts | Wacker-Chemie GmbH (DE) | 1994-02-23 | — | — | EP | disclosed |