Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025920 | 0.79 | FFAR1 (0.57) | ESR2FFAR1AKR1B1ALDH1A1GRIA2 | |
| SCHEMBL7795400 | 0.79 | ESR2 (0.54) | ESR2FFAR1AKR1B1ALDH1A1CYP1A2 | |
| SCHEMBL7791084 | 0.78 | RAB9A (0.39) | ESR2FFAR1AKR1B1ALDH1A1NPC1 | |
| SCHEMBL2404 | 0.77 | ESR2 (0.47) | ESR2FFAR1AKR1B1ALDH1A1CYP1A2 | |
| SCHEMBL1232129 | 0.76 | FFAR1 (0.38) | FFAR1ALDH1A1CYP3A4HSD17B10RAB9A | |
| SCHEMBL4618290 | 0.75 | ALDH1A1 (0.56) | FFAR1ALDH1A1NPC1RAB9ACASP3 | |
| SCHEMBL3133 | 0.74 | PDCD1 (0.43) | FFAR1AKR1B1 | |
| SCHEMBL1232755 | 0.73 | ALDH1A1 (0.45) | FFAR1ALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL9846013 | 0.73 | TSHR (0.36) | ESR2FFAR1AKR1B1ALDH1A1CYP1A2 | |
| SCHEMBL25170808 | 0.72 | NOS3 (0.42) | ALDH1A1CYP1A2CYP3A4ALOX15NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5672596-A | ANIMAL GROWTH CONTROLLERS | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |