Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | PGR | P06401 | 4/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | IL6 | P05231 | 1/20 | 0.36 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706329 | 0.90 | SHBG (0.44) | SHBGLMNAMAPTCYP3A4PGR | |
| Mespirenone SCHEMBL18218179 | 0.79 | PGR (0.48) | SHBGLMNAMAPTCYP3A4PGR | |
| Mespirenone SCHEMBL637071 | 0.79 | PGR (0.48) | SHBGLMNAMAPTCYP3A4PGR | |
| SCHEMBL7795441 | 0.75 | LMNA (0.55) | LMNAMAPTCYP3A4PGRAR | |
| SCHEMBL11095036 | 0.75 | SHBG (0.44) | SHBGLMNAMAPTCYP3A4PGR | |
| SCHEMBL11095042 | 0.75 | SHBG (0.44) | SHBGLMNAMAPTCYP3A4PGR | |
| SCHEMBL6554421 | 0.75 | SHBG (0.50) | SHBGLMNAMAPTCYP3A4PGR | |
| SCHEMBL11507824 | 0.74 | LMNA (0.53) | SHBGLMNAMAPTCYP3A4PGR | |
| SCHEMBL11129293 | 0.74 | SHBG (0.45) | SHBGLMNAMAPTCYP3A4PGR | |
| SCHEMBL11111005 | 0.74 | SHBG (0.45) | SHBGLMNAMAPTCYP3A4PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863760-B1 | USE OF ANTIMINERALOCORTICOID COMPOUNDS AGAINST DRUG WITHDRAWAL SYNDROME | AVENTIS PHARMA SA (FR) | 2001-12-05 | — | — | EP | claimed |