Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265824 | 0.87 | MEN1 (0.33) | — | |
| SCHEMBL5424004 | 0.76 | — | — | |
| SCHEMBL6267051 | 0.75 | RAB9A (0.39) | — | |
| SCHEMBL109095 | 0.73 | TDP1 (0.31) | — | |
| Tromethamine SCHEMBL2770507 | 0.69 | — | — | |
| Tromethamine SCHEMBL6235066 | 0.68 | — | — | |
| SCHEMBL28327715 | 0.66 | — | — | |
| Tromethamine SCHEMBL11209439 | 0.65 | MEN1 (0.39) | — | |
| SCHEMBL9005317 | 0.64 | — | — | |
| SCHEMBL9790459 | 0.64 | ALDH1A1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010044488-A1 | Flame-retarded thermoplastic resin composition | AJINOMOTO CO. INC. (JP) | 2001-11-22 | — | — | US | disclosed |