Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 6/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794883 | 0.84 | NAMPT (0.53) | NAMPT | |
| SCHEMBL7796320 | 0.83 | NAMPT (0.42) | NPC1RAB9ANAMPTNFKB1NFKB2 | |
| SCHEMBL7789524 | 0.80 | TAS1R3 (0.38) | NPC1RAB9AMAPTNAMPTTAS1R3 | |
| SCHEMBL7799029 | 0.77 | NPC1 (0.52) | NPC1RAB9AMAPTTP53NAMPT | |
| SCHEMBL7797525 | 0.74 | NAMPT (0.50) | MAPTTP53NAMPTHDAC6HDAC3 | |
| SCHEMBL7795811 | 0.74 | POLB (0.40) | MAPTLMNAHDAC6KDM4EHDAC1 | |
| SCHEMBL7796483 | 0.74 | HDAC6 (0.47) | MAPTSMN1; SMN2LMNAHDAC6HDAC1 | |
| SCHEMBL7787409 | 0.72 | HDAC6 (0.47) | L3MBTL1HDAC6HDAC3HDAC1HDAC8 | |
| SCHEMBL7796971 | 0.72 | ALDH1A1 (0.43) | RAB9AMAPTNAMPTHTTLMNA | |
| SCHEMBL7796324 | 0.72 | HDAC6 (0.63) | NAMPTHDAC6HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151317-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |