SCHEMBL7798192

SCHEMBL7798192

NNc1ccc(-n2cnnc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 4/20 0.47
CYP1A2 P05177 3/20 0.47
LMNA P02545 3/20 0.45
RXFP1 Q9HBX9 1/20 0.45
QPCT Q16769 1/20 0.41
CYP2D6 P10635 2/20 0.39
CYP3A4 P08684 1/20 0.39
IDO1 P14902 1/20 0.39
CYP2C19 P33261 1/20 0.39
PTGS2 P35354 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
KMT2A Q03164 4/20 0.37
MAPT P10636 1/20 0.36
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
CA5A P35218 1/20 0.35
CA7 P43166 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7804884 0.98 CYP2C9 (0.45) CYP2C9CYP1A2LMNARXFP1QPCT
Hydrochloric Acid SCHEMBL7917783 0.98 CYP2C9 (0.45) CYP2C9CYP1A2LMNARXFP1QPCT
SCHEMBL5779670 0.77 MAPT (0.66) CYP2C9CYP1A2LMNACYP2D6CYP3A4
Hydrochloric Acid SCHEMBL8651431 0.75 MAPT (0.63) CYP2C9CYP1A2LMNACYP2D6CYP3A4
SCHEMBL1352015 0.73 MAPT (0.56) CYP2C9CYP1A2LMNARXFP1QPCT
Hydrochloric Acid SCHEMBL3867813 0.73 AOC2 (0.50) CYP2C9CYP1A2LMNACYP2D6CYP3A4
SCHEMBL22478364 0.72 LMNA (0.45) CYP2C9CYP1A2LMNARXFP1QPCT
SCHEMBL218054 0.71 TDP1 (0.67) CYP2C9CYP1A2LMNACYP2D6CYP3A4
SCHEMBL21923049 0.69 CYP1A2 (0.52) CYP2C9CYP1A2LMNARXFP1QPCT
SCHEMBL1186988 0.69 ENPP2 (0.56) CYP2C9CYP1A2LMNARXFP1QPCT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630374-B1 IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES MERCK SHARP & DOHME (GB) 2001-09-05 EP disclosed
EP-0741722-B1 TRIAZOLE DERIVATIVES MERCK SHARP & DOHME (GB) 2001-06-13 EP disclosed
US-6150391-A Diazabicyclo-octane derivatives as 5-HT receptor ligands MERCK SHARP & DOHME LTD. 2000-11-21 US disclosed
US-6140347-A Azetidine, pyrrolidine and piperidine derivatives as 5-HT receptor agonists MERCK SHARP & DOHME LTD. (GB) 2000-10-31 US disclosed
US-6107321-A Diazabicyclooctane derivatives having selective 5-HT1Dalpha agonist activity MERCK SHARP & DOHME LTD. (GB) 2000-08-22 US disclosed
US-6054456-A Substituted piperazine derivatives MERCK SHARP & DOHME LTD. (GB) 2000-04-25 US disclosed
US-6054469-A Substituted tetrahydropyridine derivatives acting on 5-HT receptors MERCK SHARP & DOHME LTD. (GB) 2000-04-25 US disclosed
US-6051572-A Azetidine, pyrrolidine and piperidine derivatives MERCK SHARP & DOHME LTD. (GB) 2000-04-18 US disclosed
US-6051591-A Diazabicyclooctane derivatives MERCK SHARP & DOHME LTD. (GB) 2000-04-18 US disclosed
US-6048878-A Substituted piperidine derivatives as selective agonists of 5-HT receptors MERCK SHARP & DOHME LTD. (GB) 2000-04-11 US disclosed
WO-1995032196-A1 PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES OF INDOL-3-YLALKYL AS 5-HT1D-ALPHA AGONISTS MERCK SHARP & DOHME LIMITED (GB) 1995-11-30 WO disclosed
WO-1995021166-A1 TRIAZOLE DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1995-08-10 WO disclosed
WO-1995021167-A1 TRIAZOLE DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1995-08-10 WO disclosed
EP-0651749-A1 IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1995-05-10 EP disclosed
EP-0630374-A1 IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1994-12-28 EP disclosed
CN-1089262-A 1,2 of 4-replacement, the 4-triazole derivative MERCK SHARP & DOHME (GB) 1994-07-13 CN disclosed
WO-1994003446-A1 4-SUBSTITUTED 1,2,4-TRIAZOLE DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1994-02-17 WO disclosed
WO-1994002477-A1 IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1994-02-03 WO disclosed
EP-0581538-A1 4-Substituted 1,2,4-triazole derivatives MERCK SHARP & DOHME LTD. (GB) 1994-02-02 EP disclosed
WO-1993018029-A1 IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1993-09-16 WO disclosed