Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | ILK | Q13418 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144993 | 0.86 | KMT2A (0.69) | NPC1RAB9ASMN1; SMN2DYRK1AKMT2A | |
| SCHEMBL95067 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2DYRK1APPARA | |
| SCHEMBL2400142 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2DYRK1AKMT2A | |
| SCHEMBL31276816 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2DYRK1APPARA | |
| SCHEMBL30627231 | 0.79 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2DYRK1AKMT2A | |
| SCHEMBL12318433 | 0.79 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2DYRK1AKMT2A | |
| SCHEMBL29751964 | 0.79 | CYP3A4 (0.75) | NPC1RAB9ASMN1; SMN2DYRK1APPARA | |
| SCHEMBL778048 | 0.79 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2DYRK1AKMT2A | |
| SCHEMBL11459521 | 0.79 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2DYRK1AKMT2A | |
| SCHEMBL2748547 | 0.79 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2DYRK1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3568399-B1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | AGRIMETIS LLC (US) | 2026-04-22 | — | — | EP | disclosed |
| US-20200148716-A1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | AGRIMETIS, LLC (US) | 2020-05-14 | — | — | US | disclosed |
| US-20200148716-A1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | AGRIMETIS, LLC (US) | 2020-05-14 | — | — | US | disclosed |
| US-10570165-B2 | Aziridine spinosyn derivatives and methods of making | AGRIMETIS, LLC (US) | 2020-02-25 | — | — | US | disclosed |
| US-10570165-B2 | Aziridine spinosyn derivatives and methods of making | AGRIMETIS, LLC (US) | 2020-02-25 | — | — | US | disclosed |
| EP-3568399-A1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | Agrimetis, LLC (US) | 2019-11-20 | — | — | EP | disclosed |
| US-20180291053-A1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | AGRIMETIS, LLC (US) | 2018-10-11 | — | — | US | disclosed |
| WO-2018132288-A1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | AGRIMETIS, LLC (US) | 2018-07-19 | — | — | WO | disclosed |
| US-20170136007-A1 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | THE FEINSTEIN INST MEDICAL RES (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170136007-A1 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | THE FEINSTEIN INST MEDICAL RES (US) | 2017-05-18 | — | — | US | disclosed |
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080051415-A1 | Novel piperazines, pharmaceutical compositions and methods of use thereof | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2008-02-28 | — | — | US | disclosed |
| US-20080051415-A1 | Novel piperazines, pharmaceutical compositions and methods of use thereof | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2008-02-28 | — | — | US | disclosed |
| US-20080051415-A1 | Novel piperazines, pharmaceutical compositions and methods of use thereof | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2008-02-28 | — | — | US | disclosed |
| WO-2007146066-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CRITICAL THERAPEUTICS, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| US-20060194859-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-08-31 | — | — | US | disclosed |
| US-7091228-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1633722-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Pharmaceuticals Corporation (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004100881-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040224997-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570165-B2 | Aziridine spinosyn derivatives and methods of making | AAAS, AZI2, NISCH | NPC1 3457/4885RAB9A 442/4885SMN1; SMN2 404/4885 |
| US-20040224997-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | FABP4, GPR119, LIPC | NPC1 187/4885RAB9A 2066/4885SMN1; SMN2 3975/4885 |
| US-20060194859-A1 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | FABP4, GPR119, LIPC | NPC1 187/4885RAB9A 2066/4885SMN1; SMN2 3975/4885 |
| US-20200148716-A1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | AAAS, AZI2, NISCH | NPC1 3457/4885RAB9A 442/4885SMN1; SMN2 404/4885 |
| US-20170136007-A1 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CHRNA7, CHRNA5, CHRM5 | NPC1 2069/4885RAB9A 1762/4885SMN1; SMN2 468/4885 |
| US-20180291053-A1 | AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING | AAAS, AZI2, NISCH | NPC1 3457/4885RAB9A 442/4885SMN1; SMN2 404/4885 |
| US-20080051415-A1 | Novel piperazines, pharmaceutical compositions and methods of use thereof | CHRNA7, CHRNA5, CHRNA2 | NPC1 1706/4885RAB9A 1898/4885SMN1; SMN2 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.