Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800929 | 0.89 | LMNA (0.44) | SYKCTSSNPC1CTSKCTSL | |
| SCHEMBL7131218 | 0.83 | PPARA (0.51) | SYKCTSSPPARAPPARGNPC1 | |
| SCHEMBL7139147 | 0.80 | CTSK (0.44) | SYKCTSSSIGMAR1ATMCTSK | |
| SCHEMBL7797009 | 0.76 | SYK (0.45) | SYKCTSSPPARACTSK | |
| SCHEMBL7796788 | 0.74 | HDAC3 (0.44) | SYKLTA4HSIGMAR1ACEMAPT | |
| SCHEMBL24365709 | 0.74 | SYK (0.49) | SYKCTSSPPARAPPARGSIGMAR1 | |
| SCHEMBL10238709 | 0.73 | ATM (0.56) | SYKCTSSKLK5ATMCTSK | |
| SCHEMBL2736627 | 0.73 | ATM (0.56) | SYKCTSSKLK5ATMCTSK | |
| SCHEMBL7135516 | 0.73 | CTSS (0.55) | SYKCTSSPPARAPPARGATM | |
| SCHEMBL18085404 | 0.73 | SYK (0.60) | SYKKLK5KLK7IDO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159260-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000055124-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |