Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799740 | 0.89 | SYK (0.47) | NPC1CTSKCTSSSYKCTSL | |
| SCHEMBL6940690 | 0.81 | HTT (0.59) | LMNASMN1; SMN2HTTCTSKCTSS | |
| SCHEMBL6404796 | 0.81 | HTT (0.59) | LMNASMN1; SMN2HTTCTSKCTSS | |
| SCHEMBL6182065 | 0.81 | CTSS (0.58) | HTTCAPN1CAPN2CTSKCTSS | |
| SCHEMBL7136768 | 0.81 | CAPN1 (0.41) | LMNASMN1; SMN2HTTCAPN1CAPN2 | |
| SCHEMBL6946489 | 0.79 | HTT (0.50) | LMNASMN1; SMN2HTTCTSKCTSS | |
| SCHEMBL6943807 | 0.79 | HTT (0.50) | LMNASMN1; SMN2HTTCTSKCTSS | |
| SCHEMBL18086889 | 0.77 | CTSK (0.55) | LMNASMN1; SMN2HTTCTSKCTSS | |
| SCHEMBL2723527 | 0.77 | LMNA (0.52) | LMNASMN1; SMN2HTTNPC1CTSK | |
| SCHEMBL7133778 | 0.77 | CTSL (0.43) | HTTCAPN1CAPN2CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159260-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000055124-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |