Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559647 | 0.93 | HDAC6 (0.45) | HDAC6L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL6561300 | 0.80 | GAA (0.39) | HDAC6L3MBTL1KDM4EMEN1KMT2A | |
| Piperazine SCHEMBL7803531 | 0.75 | ALDH1A1 (0.35) | HDAC6L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL6956521 | 0.74 | MAPT (0.42) | HDAC6L3MBTL1KDM4EMEN1KMT2A | |
| Phenylpiperazine SCHEMBL7795027 | 0.70 | GAA (0.46) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6560382 | 0.70 | ALDH1A1 (0.50) | HDAC6L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL7803549 | 0.67 | HTR6 (0.53) | LMNAHTR2A | |
| SCHEMBL6962159 | 0.67 | L3MBTL1 (0.40) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL3442752 | 0.67 | ALDH1A1 (0.53) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL7795033 | 0.66 | MAPT (0.40) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075469-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 2001-02-14 | — | — | EP | disclosed |
| WO-2000052001-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-09-08 | — | — | WO | disclosed |