Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7798214 | 0.83 | ACHE (0.59) | ACHEDRD2MAPTTRPV6KMT2A | |
| SCHEMBL7804112 | 0.82 | CFTR (0.40) | ACHECFTRPARP1ALDH1A1MAPT | |
| SCHEMBL7804089 | 0.81 | HTR7 (0.44) | ACHECFTRHTR7ALDH1A1MAPT | |
| SCHEMBL3358021 | 0.80 | HTR7 (0.47) | ACHEHTR7DRD2SLC6A4ALDH1A1 | |
| SCHEMBL7806978 | 0.79 | KDM4E (0.47) | ACHECFTRHTR7DRD2SLC6A4 | |
| SCHEMBL3354104 | 0.78 | DRD2 (0.60) | ACHEHTR7DRD2SLC6A4ALDH1A1 | |
| SCHEMBL7798179 | 0.78 | HTR1D (0.46) | PARP1DRD2SLC6A4ALDH1A1TRPV6 | |
| SCHEMBL7805698 | 0.78 | HTR7 (0.45) | ACHEHTR7DRD2SLC6A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8172775 | 0.77 | HTR1D (0.45) | PARP1DRD2SLC6A4ALDH1A1LMNA | |
| SCHEMBL3355827 | 0.77 | HTR7 (0.42) | ACHEHTR7DRD2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |