Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7525468 | 0.72 | DRD4 (0.74) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL7812155 | 0.68 | DRD2 (0.49) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL25224186 | 0.67 | SLC6A4 (0.51) | SIGMAR1CYP2D6ACHE | |
| SCHEMBL21397331 | 0.65 | DRD2 (0.50) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL25206928 | 0.65 | ACHE (0.49) | CYP2D6LMNAALDH1A1ACHE | |
| SCHEMBL21396908 | 0.65 | DRD2 (0.53) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL14922286 | 0.65 | SMN1; SMN2 (0.59) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL493491 | 0.65 | SLC6A4 (0.44) | SIGMAR1POLB | |
| SCHEMBL7812268 | 0.65 | HTR1A (0.67) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL29639702 | 0.65 | DRD2 (1.00) | DRD2DRD3HTR1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8325257-A | — | — | None | — | — | JP | disclosed |
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| CN-1064356-C | New Piperazine, piperidine and 1,2,5,6-tetrahydropyridine compounds, process for preparation thereof and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | CN | disclosed |
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |
| JP-H08325257-A | NEW PIPERAZINE, PIPERIDINE AND 1,2,5,6-TETRAHYDROPYRIDINE COMPOUND, AND THEIR PRODUCTION AND MEDICAL COMPOSITION CONTAINING THE SAME | ADIR | 1996-12-10 | — | — | JP | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |