Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7525468 | 0.76 | DRD4 (0.74) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL7811843 | 0.74 | ADRA1B (0.41) | DRD2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL2114371 | 0.72 | DRD2 (0.55) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL9175441 | 0.71 | HTR1A (0.57) | DRD2HTR1A | |
| SCHEMBL7818353 | 0.71 | ADRA1D (0.41) | DRD2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL3187564 | 0.69 | HTR1A (0.57) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL7805258 | 0.68 | DRD2 (0.47) | DRD2DRD3HTR1AADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL10408656 | 0.68 | HTR1A (0.53) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL9014693 | 0.68 | SIGMAR1 (0.55) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL8520072 | 0.68 | HTR1A (0.48) | DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| CN-1064356-C | New Piperazine, piperidine and 1,2,5,6-tetrahydropyridine compounds, process for preparation thereof and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | CN | disclosed |
| CN-1142494-A | New Piperazine, piperidine and 1,2,5,6-tetrahydropyridine compounds, process for preparation thereof and pharmaceutical compositions containing them | ADIR (FR) | 1997-02-12 | — | — | CN | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |