Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 4/20 | 0.49 |
| ▸ | CTSD | P07339 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | CASP9 | P55211 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945318 | 0.94 | CTSD (0.46) | CMA1CTSDCTSLCTSSCTSK | |
| SCHEMBL7806366 | 0.89 | CTSL (0.47) | CMA1CTSDCTSLCTSSCTSB | |
| SCHEMBL8492203 | 0.86 | CTSD (0.54) | CTSDCTSLCTSSCTSBCTSK | |
| SCHEMBL8736216 | 0.84 | CTSD (0.53) | CMA1CTSDCTSSCTSKHTRA1 | |
| SCHEMBL7807985 | 0.83 | CTSD (0.56) | CTSDCTSLCTSSCTSBCTSK | |
| SCHEMBL7806370 | 0.82 | CTSD (0.49) | CMA1CTSDCTSLCTSSCTSB | |
| SCHEMBL7801249 | 0.81 | CASP3 (0.46) | CTSDCTSLCTSSCTSBCTSK | |
| SCHEMBL8041651 | 0.81 | MME (0.47) | CMA1CTSDCTSSCTSKCASP3 | |
| SCHEMBL8364492 | 0.81 | CTSD (0.48) | CMA1CTSDCASP3CASP7 | |
| SCHEMBL8361286 | 0.80 | CTSD (0.47) | CMA1CTSDCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0721449-A1 | INHIBITORS OF $g(b)-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995009838-A1 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-04-13 | — | — | WO | disclosed |