Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 4/20 | 0.43 |
| ▸ | ANPEP | P15144 | 3/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945772 | 0.89 | LTA4H (0.56) | LAP3LTA4HREN | |
| SCHEMBL6558174 | 0.84 | RIPK1 (0.46) | LAP3ANPEPRNPEPDNPEPSLC15A1 | |
| SCHEMBL6558171 | 0.84 | RIPK1 (0.46) | LAP3ANPEPRNPEPDNPEPSLC15A1 | |
| Hydrochloric Acid SCHEMBL7348250 | 0.82 | LAP3 (0.44) | LAP3ANPEPRNPEPDNPEPSLC15A1 | |
| SCHEMBL7412831 | 0.78 | SLC15A1 (0.50) | LAP3ANPEPRNPEPDNPEPSLC15A1 | |
| SCHEMBL7412834 | 0.78 | SLC15A1 (0.50) | LAP3ANPEPRNPEPDNPEPSLC15A1 | |
| Hydrochloric Acid SCHEMBL6558239 | 0.77 | CYP1A2 (0.47) | LAP3ANPEPRNPEPDNPEPSLC15A1 | |
| Hydrochloric Acid SCHEMBL7348243 | 0.76 | SLC15A1 (0.46) | LAP3ANPEPRNPEPDNPEPSLC15A1 | |
| SCHEMBL7423810 | 0.75 | LTA4H (0.57) | LAP3LTA4HREN | |
| Hydrochloric Acid SCHEMBL6558386 | 0.75 | HRH4 (0.45) | LAP3ANPEPRNPEPDNPEPSLC15A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0721449-A1 | INHIBITORS OF $g(b)-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995009838-A1 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-04-13 | — | — | WO | disclosed |