Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.59 |
| ▸ | NSD2 | O96028 | 3/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | S100A4 | P26447 | 7/20 | 0.55 |
| ▸ | CDC25B | P30305 | 3/20 | 0.55 |
| ▸ | PTPRC | P08575 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.53 |
| ▸ | PADI1 | Q9ULC6 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816501 | 0.91 | S100A4 (0.54) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL7818534 | 0.91 | S100A4 (0.54) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL7817043 | 0.80 | ALDH1A1 (0.45) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL5915065 | 0.80 | TDP2 (0.81) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL8545907 | 0.78 | TDP2 (0.59) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL5915061 | 0.78 | GAA (0.86) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL9267635 | 0.76 | TDP2 (0.74) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL3418850 | 0.75 | MEN1 (0.55) | TDP2PLCG1CES1MEN1THRB | |
| SCHEMBL460433 | 0.75 | TDP2 (1.00) | TDP2NSD2PAX8ABL1PLCG1 | |
| Phanquone SCHEMBL462025 | 0.75 | MEN1 (1.00) | TDP2NSD2PAX8ABL1PLCG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| EP-0639183-B1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA (IT) | 1998-07-01 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |
| EP-0639183-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1995-02-22 | — | — | EP | disclosed |
| WO-1992015566-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-17 | — | — | WO | disclosed |